What do you want in a serum for dry skin? Let us ask a more general question what does the world want in a serum for dry skin? What is the opposite of dry of course it is wet so we want a serum that will foremost hydrate our dry skin. It can be very painful to have itchy, dry, and flaky skin. If you have this type of red and sore skin then you need to find a serum that will decidedly hydrate the skin and remove the dead skin cells that are making the skin look dry, tired and old.