Best Sam E Supplements

(Last Updated On: November 6, 2019)

Sam E is an element produced naturally in the body and helps with bodily functions. It is a vital component in keeping the body healthy. You can get this element in supplement form as well. If your body’s sam e levels run down then these supplements can be used by the body to elevate the levels to normal levels.   

Natures Trove SAM-e 200mg Daily Supplement 

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Their process starts with using the highest level of active S.S. Isomer and it is manufactured under strictly controlled GMP guidelines. The supplements are free of allergens, artificial coloring, GMO, KOSHER-CERTIFIED. 

The above observation is good but the company does not supply any of the data to support these statements. Where are the literature, the scientific evidence, and the research study results? The company claims that sam-e–S-adenosylmethionine–will accomplish the same things that antidepressants–serotonin and dopamine–but without all the negative side effects. It can help with depression and all the symptoms that come with it but in a natural way, it eases the depression.

JOINT HEALTH: Are you experiencing joint discomfort and decreased range of motion? Clinical studies involving tens of thousands of participants, including a report by the 

Agency for Healthcare Research and Quality (A division of the U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES), have shown that SAMe can be as effective as NSAIDs (Nonsteroidal Anti-inflammatory Drugs) to help maintain joint flexibility & mobility and overall joint health.      

The company claims that environmental hazards can cause oxidative stress and that sam-e can restore an important antioxidant in the body which is Glutathione. And supposedly it can help to ease fibromyalgia symptoms according to studies. Again, the results or the links to these studies was not noted. So, is this a true statement?

Feedback: The product has had only 55 reviews written about it so it is not a popular commodity on the market today. This in no way takes from the quality of the product. These very reviews will make this a famous product among consumers. This customer’s mom takes the product and the mother has taken many sam-e products. This particular one can stand up to those other ones with no problems. 

The mother says that she can tell the difference when she does not take these supplements because they give her a calm that helps her through the day. But this sounds like her mother’s body has become addicted to the supplement because it makes her feel good. She says it is a high-quality supplement that does not cost a lot of money. She likes this fact and she appreciates a company who keeps her pocketbook in mind and they make a high-quality product. She will stick with this with a company that thinks this way. But she really does not know that the company really thinks this way. The product was rated 5-stars. 

This is one of the most honest reviews ever written. The customer says the product did not help them at all. The customer said it could have been them and not the product. The consumer rated the product 3-stars and is brutally honest in the review of the product. It takes courage to say it could be you and not the product that is causing it not to work.

The customer says they were looking for an organic alternative to drinking coffee so they could feel good. They want to feel good, happy and outstanding without drinking too much coffee. This product is just what the customer needed. The customer had a routine they follow:

1) I take just ONE Sam-e in the morning. It gives me all day energy.

2) My overall mood now is positive and happy; I can tell the difference after I take my daily Sam-e.

3) I feel peppy all day.

4) My focus and concentration have improved 100 percent since I have taken these caps.

The customer notes that they do not take the supplement in the evening because they could not sleep. They suggest that you do not take the supplement after 6:00 p.m. But this does not mean that everyone who takes this supplement in the evening will have trouble sleeping just because this person did. The person said there were other benefits they received from taking the product. Their main reason for taking the supplement was so they could feel good naturally without any side effects. They rated the product 5-stars.

This customer gives the supplement for her dog but the supplement was not designed for dogs it was designed for human consumption. The supplement may hurt the dog more than help the dog. The dog has a sensitive stomach and the supplement is supposed to be helping the dog. The dog needs to go to the vet because she may have serious stomach issues. Is this right/fair to be giving this human supplement to the dog? The dog was very small in stature which may make giving the dog a human supplement even worse.

best sam e supplements

EZ Melts SAM-e for Mood Sublingual Vitamins, Vegan, Zero Sugar, Soft Lemon Flavor

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The product improves mood and cognitive health the company says. Supports the levels of the neurotransmitters serotonin and dopamine which make the brain and body feel good. Also, the supplement will help the body and brain feel good the company claims. It helps with liver health, detox, and joint health. It contains 60 lemon-flavored, fast melting tablets. 

Feedback: The product has had only 39 reviews written about it and is not a well-known product on the market. The customer has tried sam-e in capsule and tablet form. The customer says they would feel happy for a while then they would hit a snag in their digestive tract and the happy mood would dissipate. They could not troubleshoot the problem so they looked for a liquid sam-e product. They found this product and they gave it a try.

The person has run into stomach problems taking sam-e in the past. But this sam-e product they have been taking two tablets in the morning. It is a low-dose but it has helped the person stay in an upbeat mood and they say it lasts. They started taking the supplement intermittently but the positive mood has remained. They are trying to stop taking the supplement altogether as their mood as stabilize overall. The customer recommends the product and gave it a 5-star rating. The customer also said this supplement has been very easy on their stomach and they no longer have issues with their stomach. 

The customer has had issues with anxiety but this supplement has slowed down her anxiety. She says since taking the supplement she is remembering better and she is thinking more clearly. The customer thinks this is a vitamin but it is not a vitamin. The customer rated the product 4-stars because it is too expensive for a 30-day supply. It has helped the customer a lot. 

The customer’s son has MTHFR--stands for methylenetetrahydrofolate reductase. It’s getting attention due to a genetic mutation that may lead to high levels of homocysteine in the blood and low levels of folate and other vitamins–they tried other methyl donor but they over stimulated the son’s system and did not calm his condition. 

Dr. Lynch–who he is is unknown–says he gave his kids this supplement before they went to bed. The customer gave the supplement to the son and the son went to sleep and slept peacefully through the night. The son wakes up feeling rested but what correlation does the son sleeping well have to with his condition? The customer rated the product 5-stars.  

It seems like people are taking this supplement so they can be happy and feel good. This product really is not an antidepressant so it cannot really cure depression. People may become addicted to the supplement when they need more extensive help to stabilize their emotions. These supplements may be good for temporary fatigue but not for long term depression. What is concerning is that people may become addicted to these supplements to feel happy instead of trying to get off these supplements so their body can naturally stabilize the moods.     

One customer took the supplements but is using some good sense because they are slowly weaning themselves off the supplements. They are feeling normal without taking the supplements all the time. This should be the objective of every person taking this supplement–to stop taking it when their mood stabilizes over the long run. 

SAM-e 400mg by Nature’s Trove – 60 Enteric Coated Caplets

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This is the same company–that manufactured the first product we reviewed above–is dedicated to manufacturing the highest-quality supplement on the market. They charge a reasonable price and the rest of this product description is identical to the one written in the first review in this article. 

Feedback: The product has had 70 reviews written about it so it has not had much feedback from the market as of yet. The first review does not give much insight into how well this product works in general or for the customer specifically. The client says they have taken the “popular” brands that were coated to protect the supplement from the stomach acids. The customer supposes that the supplement is absorbed through the small intestine but whether this is true or not remains to be seen. 

The customer tried the less expensive supplements that did not work as well as the expensive ones. Then the customer tried these supplements but they did not say whether they worked or not. So this is a useless review because we do not know if the product helped the client or not. The client rated the product b 5-stars but why? 

Loungeboy, wrote this review and it seems a bit extreme. He has tried other sam e supplements that helped with arthritic pain but he had to stop because these brands became too expensive. He tried this brand because it stayed reasonably priced. He says after taking the medication–about 90 minutes– his stomach pain was so severe he thought he may have to go to ER. He thinks it was the supplement because this was all he took. So, he will not purchase any more products from this company.

He rated the product one-star and he will not buy products on Amazon because he thinks it is a mistake. But it is unlikely that the supplements were the cause of his severe stomach discomfort even though he took them on an empty stomach. This could have been his first mistake and he may have some serious stomach issues that this supplement triggered. It does not seem reasonable that the company would develop a product that would cause a person to experience serious stomach pains. The supplements are designed with a protective coating so it will absorb safely into the bloodstream.   

The customer usually takes prenatal and sam e at the same time. But the customer was getting stomach aches from taking this combination without food. The customer would take the combination of pills and get nauseous as we said. The customer started taking the vitamins with food and she says she took the vitamins at opposite times she took the sam e. Her mood improved slightly but this product did not work as well as the more expensive ones did. She likes it that these supplements are cheaper and have a lot of tablets in the container. 

The customer claims the product ripped his stomach apart because he had horrible stomach pain. He says the pain stopped after 2 or 3 days of not taking the supplements. He thought he had cancer or a kidney stone. He says the company had refunded his money and the product was not as effective as the other supplements he took. He read other reviews that stated those customers had terrible stomach pain from taking this supplement. This customer needs to have his stomach checked out because he should not have experienced stomach pain like he did from taking the supplements. The customer rated the product one -star. 

best sam e supplements

Pure Encapsulations – Sam E (S-Adenosylmethionine)

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The formula will help cognitive health as well as the company claims. The product will also help with proteoglycan–a compound consisting of a protein bonded to glycosaminoglycan groups, present especially in connective tissue.– synthesis and it will protect the proteoglycans as well. 

Feedback: The product received only 54 reviews but it can become a popular product in the market. The customer says the product’s seal was broken when he received it and this is why he rated the product 4-stars. He says he took one 800mg tablet and it did not upset his stomach as the other supplements did that he was taking but he did not say if it helped him or not. So, we do not know if the product is effective or not. 

Genius Joy – Serotonin Mood, Nootropic Dopamine Stack w/Sam-E

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 The product contains serotonin, SAM-e, Rhodiola, ginseng and 11 more focus boosting vitamins and minerals for mood support and anxiety relief. The product is a natural mood enhancer that can be used instead of antidepressants. It will clear the fog naturally and it can be used by professionals, gamers, athletes or it can be used by anybody. 

Feedback: The product has had over 2700 reviews written about it so it is a popular product on the market. The Customer says they have used this company’s products before and they have always liked them because they were high quality. The customer tried this particular product and they said it did nothing for them. It did not upgrade their mood. The customer rated the product 3-stars because it did not affect them at all. This is rather a high rating considering the product did not help the customer at all.      


We have covered some Sam E supplements in this article that may help you temporarily if you are suffering from depression. They can enhance the mood for a time until your emotions stabilize and you feel normal without taking these supplements to help you feel good. Be careful when taking these supplements because you could get addicted to them. Read the reviews and decide which product is best for you. As we have discussed before there is a danger of people taking these supplements over the long term and they can become addicted to them. The danger is that people will get used to feeling good after taking these supplements that they will depend on them to feel good.    

If a person has been taking these supplements for a long time and they are not really improving their emotional state then they need to seek professional help with a medical professional then they can be cured of their issues permanently.  

Taking these supplements for a long term fix will not really help a person return to a healthy state of mind. 

Written by Irina Radosevic MD
Irina graduated from the University of Belgrade, School of Medicine as a Doctor of Medicine (MD) and spent over 3 years working in the Clinical Hospital Center Zvezdara, in the Department of Emergency Medicine. She also undertook a postgraduate in Cardiology from the same University and had previously worked for over a year as a Physician and Nutritionist Dietitian for the Fitness club Green Zone. She eventually left her chaotic but fulfilling job in the ER to pursue her passion of writing, travelling and mountain climbing which has included writing a first aid course for the alpine club of Belgrade. Irina currently works as a VA for PintMedia focusing on medical and travel writing. Feel free to connect with Irina on LinkedIn and FaceBook. Her CV can be seen here.